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For reasons that are lost to the recesses of time, I've been using Adobe's InDesign to make Darwin Eats Cake. Todd decided to make The Avengner! using Illustrator, which seems the more sensible and obvious choice. I may try it myself in the future.
Hat tip to Tasey (rhymes with "spacey") and Cim (alliterates with "cantankerous") for Evolötion.